导师介绍 | ||
导师姓名 | 许旭 | |
导师性别 | 男 | |
职务职称 | 教授 | |
所在院系 | 化学与环境工程虎扑nba | |
一级学科 | 化学工程与技术 | |
二级学科 | 制药工程 | |
研究方向 | 药物分析与质量控制 | |
联系电话 | 60873372, 18017581856 | |
电子邮箱 | ||
个人简介 | ||
分析化学教研室教授,化工虎扑nba分析测试中心主任。1991年开始至今一直从事色谱与仪器分析及其应用方面的研究工作,包括手性药物拆分、中药复方与有效成分研究、食品分析、生物大分子分离分析、体液药物分析、以及分析仪器等方面的研究。主持承担国家自然科学基金、上海市自然科学基金、企业委托课题等。在Journal of Chromatography A、International Journal of Mass Spectrometry、Frontiers in Plant Science、Journal of the American Oil Chemists Society、Chirality等杂志发表学术论文163篇(其中SCI论文82篇),授权专利17项。 | ||
学习与工作经历 | ||
1996年在中国药科大学获博士学位。中科院大连化学物理研究所博士后。之后在上海市药品检验所任副研究员、副主任(其中1998.11-1999.7到瑞典Uppsala University访问学者)。2000.6到中科院上海有机化学研究所,先后任副研究员、色谱组组长、研究员。2009.7到上海应用技术虎扑nba化学与环境工程虎扑nba工作。 | ||
科研工作与成果 | ||
近期发表的代表性SCI论文: 1. Dan-Yang Shi, Yu Zheng, Qiang-Sheng Guo, Can Gong, Xu Xu*, Jian-Ping Gao*, Determination of Total Phenol and Six Polyphenolic Components in Cinnamomi Cortex Polyphenol Extract by Quantitative Nuclear Magnetic Resonance Spectroscopy, Analytical Methods, 2023, 15, 6561–6570 2. Yu-Lin Shen, Si-Jia Zhuang, Fan Yang, Can Gong, Xu Xu*. Prefabricated platinum nanomaterial matrix for MALDI-MS imaging of oligosaccharides and lipids in plant tissues. Frontiers in Plant Science. 2023, 14:1105374. 3. Hongyu Sun, Siyu He(共一作者), Li Wu, Zeying Cao, Xian Sun, Mingwei Xu, Shan Lu, Mingdi Xu, Baoming Ning, Huimin Sun, Tiqiao Xiao, Peter York,Xu Xu*, Xianzhen Yin*, Jiwen Zhang*. Bridging the structure gap between pellets in artificial dissolution media and in gastrointestinal tract in rats. Acta Pharmaceutica Sinica B, 12(1): 326-338, 2022. 4. Yang Xu, Yingzhi Deng, Rongrong Ye, Can Gong, Zhaoxin Liu, Yuezhen Zhao, Yan Lu*, Jinggen Liu, Xu Xu*, MALDI-MS imaging of lipids and small molecules in rat brain tissue based on graphene oxide film pre-coated matrix, International Journal of Mass Spectrometry, 464: 116573, 2021 5. Jia- Hua Feng, Ke- Zhao Wei, Jian- Ping Gao*, Xu Xu*, Determination of adenosine phosphates in mouse myocardium tissue by HPLC with UV detection and using porous graphite carbon column, Journal of Chromatography B, 1145: 122110, 2020 6. 肖坤,龚灿,郭强胜,许旭*,定量核磁共振碳谱同时测定食用油中甘油三酯的sn-1,3和sn-2脂肪酸含量,分析化学,48(6): 802-810, 2020 7. Jia-Lin Du, Xing-Li Pei, Hai-Yan Zhao, Can Gong*, Xu Xu*, Identification of fatty acids and triacylglycerols in Schisandrae chinensis fructus oil, Journal of Analytical Chemistry, 2020, 75(8): 1024–1032. 8. 陆湘婷,张世鼎,龚灿,许旭*,基于多孔石墨碳柱和正辛烷-异丙醇流动相的高效液相色谱法分离分析食用油中的甘油三酯,分析化学,48(8):1084-1095,2020 9. Xing-Li Pei, Xiao-Ning Liu, Jia-Lin Du, Can Gong, Xu Xu*, MALDI-MS imaging of lipids in corn using a flexible ultrasonic spraying device as matrix deposition method, International Journal of Mass Spectrometry, 455: 116373, 2020 10. 赵玥祯,徐杨,龚灿,鞠钰蕊,刘兆鑫,许旭*,纳米四氧化三铁基质用于基质辅助激光解吸电离质谱法分析小分子化合物, 分析化学,49(1): 103-112,2021 11. Yang Xu, Yingzhi Deng, Rongrong Ye, Can Gong, Zhaoxin Liu, Yuezhen Zhao, Yan Lu*, Jinggen Liu, Xu Xu*, MALDI-MS imaging of lipids and small molecules in rat brain tissue based on graphene oxide film pre-coated matrix, International Journal of Mass Spectrometry, 464: 116573, 2021 12. Jia-Lin Du, Can Gong?, Xing-Li Pei, Hai-Yan Zhao, Xu Xu*, Analysis of triacylglycerols in castor oil by LC-MS and FTICR-MS based on GC-MS,Journal of Chromatographic Science, 57(2):108–115, 2019 13. 刘晓宁,裴兴丽,龚灿,许旭*,基于离子液体的基质辅助激光解吸电离质谱成像分析桑叶表面和叶脉切片中的小分子成分,分析化学,46(12): 1923~1930, 2018 14. Shi-Ding Zhang, Can Gong, Yan Lu*, Xu Xu*, Separation of triacylglycerols in edible oil by LC-MS with porous graphitic carbon column and toluene-based mobile phase, Journal of the American Oil Chemists Society, 95(10):1253-1266, 2018 15. Xinda Liu, Xiaodong Tian, Xu Xu*, Choiwan Lau, Jianzhong Lu*, Design of a Phosphinate-based Bioluminescent Probe for Superoxide Radical Anion Imaging in Living Cells, Luminescence, 33(6):1101-1106, 2018 16. Yao-Li Zhang, Can Gong, Xing-Li Pei, Yu-Liang Han, Yu-Yu Huang, Xu Xu*, Rapid quantitative determination of triglycerides in edible oils by matrix-assisted laser desorption/ionisation Fourier transform ion cyclotron resonance mass spectrometry using pencil graphite combined with 2,5-dihydroxybenzoic acid as matrix, International Journal of Mass Spectrometry, 431:56-62, 2018 17. Longwei Fang, Xianzhen Yin(共一作者), Li Wu, Yaping He, Yuanzhi He, Wei Qin, Fanyue Meng, Peter York, Xu Xu*, Jiwen Zhang*, Classification of microcrystalline celluloses via structures of individual particles measured by synchrotron radiation X-ray micro-computed tomography, International Journal of Pharmaceutics, 531(2): 658-667, 2017 18. 黄煜宇,肖坤,裴兴丽,韩玉良,龚灿,许旭*,使用尖玻片、毛细管和尖滴管三种玻璃尖端电喷雾离子化质谱分析方法. 分析化学, 46(4): 578-585, 2018 19. Xiao-Lin Shan, Xiao-Ting Liu, Can Gong, Xu Xu*, Precolumn Derivatization with Bromine to Improve Separation and Detection Sensitivity of Triacylglycerols in Edible Oil by Reversed-Phase High Performance Liquid Chromatography,Analytical Sciences, 34(3):283-289,2018 20. 赵海燕,龚灿,许旭*,反相液相色谱-质谱法使用甲酸甲胺改善甘油三酯电喷雾离子化检测灵敏度. 分析化学, 45(9): 1323-1329, 2017 21. 裴兴丽,黄煜宇,龚灿,许旭*,基于离子液体基质的大豆中寡糖成分MALDI- MS成像分析,分析化学,45(8) :1155 ~1164, 2017 22. 刘晓婷,禹珊,袁铭,郭强胜,龚灿,许旭*,固相萃取-定量核磁共振波谱法测定板蓝根饮片中的表告依春,分析化学,45(7) :1059 ~1065, 2017 23. 张耀利,裴兴丽,龚灿,韩玉良,倪天强,王帆,王盛君,卢海鹏,许旭*,大气压化学电离-高分辨质谱谱直接分析食用油中的甘油三酯,分析化学,45(2): 183-190, 2017 24. Botao Liu, Haiyan Li, Xiaonan Xu, Xue Li, Nana Lv, Vikramjeet Singh, J. Fraser Stoddart, Peter York, Xu Xu*, Ruxandra Gref*, Jiwen Zhang*, Optimized syntheses and crystalline stability of γ-Cyclodextrin metal-organic frameworks for drug adsorption,International Journal of Pharmaceutics, 514(1), 212–219, 2016 25. Xue Fu, Jianhui Li, Lianyan Wang, Bing Wu, Xu Xu*, Zongwu Deng, Hailu Zhang*, Pharmaceutical Crystalline Complexes of Sulfamethazine with Saccharin: Same Interaction Site but Different Ionization State, RSC Adv., 6(31): 26474-26478, 2016 26. Xiao-Rui Lei, Can Gong, Yao-Li Zhang, Xu Xu*, Influence of the acetamide from acetonitrile hydrolysis in acid-contained mobile phase on the ultraviolet detection in high performance liquid chromatography, Chromatographia, 79:1257-1262, 2016 27. 何榕,山晓琳,董方圆,许旭*,反相超效液相色谱-质谱联用分离分析食用油中的甘油三酯,分析化学,43(9):1377-1382, 2015 28. Xiaolong Lu, Zuhua Liao, Xue Li, Manli Wang, Li Wu, Haiyan Li, Peter York, Xu Xu*, Xianzhen Yin*, Jiwen Zhang*, Powder Technology, 281: 49-56, 2015 29. 韩玉良,张耀利,杨宇辉,黄煜宇,许旭*,简便型实时直接分析质谱进样装置,分析化学,43(3): 451-456, 2015 30. 禹珊,郭强胜,王会琳,高建平,许旭*,定量核磁共振波谱法同时测定中药虎杖中白藜芦醇和虎杖苷的含量,分析化学,43(1): 69~74, 2015 (该文2016和2017年两次被评为上年度中国精品科技期刊“F5000”论文)
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社会学术团体兼职 | ||
五种学术期刊《色谱》、《分析试验室》、《理化检验-化学分册》、《Journal of Chinese Pharmaceutical Sciences》、《应用技术学报》的编委。 | ||
主要研究方向 | ||
质谱、色谱、NMR等仪器分析方法及其应用研究。包括药物分析(中药分析、体液分析等)、食品分析(食用油分析)等。 | ||
近3年指导研究生的就业情况 | ||
近3年累计毕业11名研究生。其中1名读博,1名到政府单位,其他均在江浙沪的新药研发、分析检测相关公司。 |